We studied the reproductive characteristics, such as snout-vent length (SVL) at sexual maturity, clutch size, and egg volume, and morphological characteristics [head length (HL), head width (HW), femur length (FL), and tibia length (TL)] in Aspidoscelis deppii and A. guttata from Oaxaca, Mexico. In A. deppii, males were larger in SVL than females, whereas in A. guttata, females were larger than males. Males of A. deppii had larger morphological structures, such as HL, HW, FL, and TL, than females; in contrast, males and females of A. guttata were similar, except in TL, in which females were larger. Mean clutch size was 2.3 for A. deppii and 4.5 for A. guttata. Females of A. deppii had smaller egg volume than females of A. guttata. Both A. deppii and A. guttata respond to the environmental factors from this region, but in different ways.